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Isotretinoin

Clinical data
Pronunciation	See note at tretinoin
Trade names	Accutane (originator), subsequently many generics [1]
AHFS/Drugs.com	Monograph
MedlinePlus	a681043
License data	US   FDA: Isotretinoin
Pregnancy category	AU: X (High risk) US: X (Contraindicated)
Routes of administration	By mouth, topical
ATC code	D10AD04 ( WHO )
Legal status
Legal status	AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Variable
Protein binding	99.9%
Metabolism	Hepatic
Elimination half-life	10–20 hours
Excretion	Renal and fecal

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Active substance	isotretinoin
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• No one knows if isotretinoin caused these problems or behaviors or if they would have happened even if the person did not take isotretinoin
• Taking for the treatment of acne, especially for a long time, it is necessary to maintain the health of various immunomodulatory drugs, reducing the intestinal microflora and reduce the impact of the drug on the internal organs
• It has an antimicrobial effect

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Patients on isotretinoin have been known to become depressed or to develop other serious mental health problems.

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