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Isotretinoin

Clinical data
Pronunciation	See note at tretinoin
Trade names	Accutane (originator), subsequently many generics [1]
AHFS/Drugs.com	Monograph
MedlinePlus	a681043
License data	US   FDA: Isotretinoin
Pregnancy category	AU: X (High risk) US: X (Contraindicated)
Routes of administration	By mouth, topical
ATC code	D10AD04 ( WHO )
Legal status
Legal status	AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Variable
Protein binding	99.9%
Metabolism	Hepatic
Elimination half-life	10–20 hours
Excretion	Renal and fecal

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Undergoing accutane expert is a blood of experience and acne	Oh potential	Isotretinoin is usually taken twice a day with meals for 4 to 5 months at a time	Hoffmann-la
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The course of treatment is quite long, depending on the extent of skin lesions. Immunomodulators are prescribed along with antibiotics.

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