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Clinical data | |
---|---|
Pronunciation | See note at tretinoin |
Trade names | Accutane (originator), subsequently many generics [1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a681043 |
License data | US FDA: Isotretinoin |
Pregnancy category | AU: X (High risk) US: X (Contraindicated) |
Routes of administration | By mouth, topical |
ATC code | D10AD04 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only) |
Pharmacokinetic data | |
Bioavailability | Variable |
Protein binding | 99.9% |
Metabolism | Hepatic |
Elimination half-life | 10–20 hours |
Excretion | Renal and fecal |
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