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Fluoxetine (top), ( R )-fluoxetine (center), ( S )-fluoxetine (bottom) | |
Clinical data | |
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Pronunciation | / f l u ˈ ɒ k s ə t iː n / |
Trade names | Prozac, Sarafem, Adofen, other |
AHFS/Drugs.com | Monograph |
MedlinePlus | a689006 |
License data | US FDA: Fluoxetine |
Pregnancy category | AU: C US: C (Risk not ruled out) |
Dependence liability | Physical: Low Psychological: Low |
Addiction liability | None |
Routes of administration | By mouth |
ATC code | N06AB03 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only |
Pharmacokinetic data | |
Bioavailability | 60–80% [2] |
Protein binding | 94–95% [3] |
Metabolism | Liver (mostly CYP2D6-mediated) [1] |
Elimination half-life | 1–3 days (acute) 4–6 days (chronic) [1] [4] |
Excretion | Urine (80%), faeces (15%) [1] [4] |
Fluoxetine, Prozac, antidepressant, depression, SSRI, serotonin Depression is a common and recurring psychiatric syndrome, marked by episodes of low mood, poor self-esteem, and diminished interest and pleasure in most activities and secretaddiction.org or dorothy6.com.
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Wongproposed to retest the series for the in vitro reuptake of serotonin, norepinephrine and dopamine. Extensively hepatic by demethylation to norfluoxetine. Avoid concurrent use with clopidogrel.
Pharmacodynamics[ edit ] Fluoxetine is a selective serotonin reuptake inhibitor SSRI and does not appreciably inhibit norepinephrine and dopamine reuptake at therapeutic doses.
Fluoxetine is a potent and highly selective inhibitor of serotonin 5-HT re-uptake. Special Precautions for Fluoxetine 20mg: It was known at that time that the antihistamine diphenhydramine shows some antidepressant-like properties.
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This test, carried out by Jong-Sir Horng in May[86] showed the compound later named fluoxetine to be the most potent and selective inhibitor of serotonin reuptake of the series. Seizures, mania, hypomania or mixed manic states fluoxetine names. Two-fold increase in plasma levels of other antidepressants when combined with fluoxetine. Extensively hepatic by demethylation to norfluoxetine.
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For example, patients who are taking ketoconazole or itraconazole, antidepressants, antifungals, antihistamines, painkillers, oral contraceptives, SSRIS, and other medications for the treatment of mental health symptoms including fluoxetinesedatives or sleeping pills, medications used to manage seizures, or the supplement St. vuc.dk. Additionally, it is recommended to disclose any allergies to other medications to the prescribing physician and potentially to avoid eating grapefruit or grapefruit products as well.
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However, the significance of this levitra vs is not fully clear. A randomized clinical trial performed by the US National Institutes for Mental Health found that fluoxetine reduced acts of domestic violence in alcoholics with a history of such behavior [] A second clinical trial performed at the University of Chicago found that fluoxetine reduced aggressive behavior in patients in intermittent aggressive disorder.
After evaporation of the solvent, 5 was collected as a crystalline hydrochloride salt. Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: The other permitted antidepressants are sertraline Zoloftcitalopram Celexaand escitalopram Lexapro. Though physical dependence is normal with long-term regular use, when it occurs at the same time as psychological dependence, or cravings for Xanax and a feeling that it would be impossible to live without use of the drug, it is time to seek treatment for addiction.
Pharmacodynamics[ edit ] Fluoxetine is a selective serotonin reuptake inhibitor SSRI and does not appreciably inhibit norepinephrine and dopamine reuptake at therapeutic doses. Symptoms of overdose on alprazolam may include: However, the significance of this property is not fully clear.
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Neonatal adaptation in infants prenatally exposed to antidepressants- clinical monitoring using neonatal abstinence score.
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Norfluoxetine concentrations are approximately equal to those of the parent drug during chronic therapy, but may be substantially less following acute overdosage, since it requires at least 1—2 weeks for the metabolite to achieve equilibrium with drug interactions between lexapro and tramadol. May cause transient shift in plasma conc of tightly protein bound drugs e.
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