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Sildenafil

Clinical data
Pronunciation	/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade names	Viagra, Revatio, others
AHFS/Drugs.com	Monograph
MedlinePlus	a699015
License data	EU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy category	AU: B1 US: B (No risk in non-human studies)
Routes of administration	By mouth (tablets), IV
ATC code	G04BE03 ( WHO )
Legal status
Legal status	AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	41% (mean) [1]
Protein binding	~96%
Metabolism	Liver: CYP3A4 (major route), CYP2C9 (minor route)
Metabolites	N -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life	3–4 hours
Excretion	Feces (~80%), urine (~13%) [2]

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