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Clinical data | |
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Pronunciation | / s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil |
Trade names | Viagra, Revatio, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699015 |
License data | EU EMA: by INN, US FDA: Sildenafil |
Pregnancy category | AU: B1 US: B (No risk in non-human studies) |
Routes of administration | By mouth (tablets), IV |
ATC code | G04BE03 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only) |
Pharmacokinetic data | |
Bioavailability | 41% (mean) [1] |
Protein binding | ~96% |
Metabolism | Liver: CYP3A4 (major route), CYP2C9 (minor route) |
Metabolites | N -desmethylsildenafil (~50% potency for PDE 5 ) |
Elimination half-life | 3–4 hours |
Excretion | Feces (~80%), urine (~13%) [2] |
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Sudden vision loss in one or both eyes can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy NAION. They are the views of click at this page author and do not necessarily represent the views of hims, and are for informational purposes only, even if and to the extent that this article features the advice of physicians and medical practitioners.
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