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Clinical data | |
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Pronunciation | / s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil |
Trade names | Viagra, Revatio, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699015 |
License data | EU EMA: by INN, US FDA: Sildenafil |
Pregnancy category | AU: B1 US: B (No risk in non-human studies) |
Routes of administration | By mouth (tablets), IV |
ATC code | G04BE03 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only) |
Pharmacokinetic data | |
Bioavailability | 41% (mean) [1] |
Protein binding | ~96% |
Metabolism | Liver: CYP3A4 (major route), CYP2C9 (minor route) |
Metabolites | N -desmethylsildenafil (~50% potency for PDE 5 ) |
Elimination half-life | 3–4 hours |
Excretion | Feces (~80%), urine (~13%) [2] |
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Only 4 percent of the sites were in proper compliance, according to the Verified Internet Pharmacy Practice Sites program. Viagra is a PDE5 inhibitor, meaning it inhibits the specific enzyme that regulates blood flow to the soft tissue of the penis. Sildenafil may affect the way other medicines work, and other medicines may affect the way Sildenafil works, causing side effects.
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Erections whats viagra when blood flows into the penis. Although Viagra sildenafil whats viagra not directly interact with coumadin, Zithromax manufacturer coupon sotalolLanoxin digoxinor enalapril, it should be used cautiously in patients with underlying heart conditions.
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